Description

Sildenafil citrate is the active ingredient of Intagra 100mg which comes in the class of PDE5 inhibitor. Penile erection occurs through a physiological process. When a men is sexually aroused, this medication stimulates the release of nitric oxide is from the nerve cells in the penis and it reacts with the enzyme Guanylatecyclase. This will further results the biosynthesis of cyclic guanosine monophosphate (cGMP).cGMP is the second mediator which makes the intracellular protein kinases active and causes the relaxation of smooth muscles of the male genital area. The relaxation of these muscles results to improved blood flow. This finally leads to desired erection required for a satisfactory physical intercourse.

Safety Information

Since Sildenafil Citrate is an active ingredient, it has a tendency to interact with other medication. So always talk to your health care provider if you are under other medicine before taking this medication to avoid any serious complication. It is not possible to describe all the drug interactions. Some of the possible interactions are mentioned here:

• Cisapride
• Methscopolamine nitrate
• Nitrates like amyl nitrite, isosorbidedinitrate, isosorbidemononitrate, nitroglycerin
• Nitroprusside

This medicine may also cause interaction with the following drugs:

• Drugs for hypertension or high blood pressure
• Drugs for the treatment of HIV infection or AIDS
• Some medications used for fungal or yeast infections, like fluconazole, itraconazole, ketoconazole, and voriconazole
• Cimetidine
• Erythromycin
• Rifampin